Technologies
Genetic Testing
Using Illumina's Genome-wide SNP Array ASA chip capable of decoding more than 600,000 full-length genome SNPs per person
Own your genome files
Individuals can freely manage the entire genome file, not just the test results.
Quality control of large-scale genome information
Sample mix-up tracking, Monitoring sample contamination and call-rates and SNP error rate measurement technology
Sample mix-up tracking, Monitoring sample contamination and call-rates and SNP error rate measurement technology
Establish a genetic influence database selected through genetic marker public database information and its own disease marker selection algorithm, and analyze genetic influence and establish predictive models using more than 500,000 genetic and epidemiological data from 150,000 Koreans and UK public cohort genome information I did.
By genome analysis experts
We have an analysis team composed of researchers from the Korea Centers for Disease Control and Prevention, experts in artificial intelligence, and master's and doctoral level researchers with experience in disease genome analysis. The team members have reported more than 80 research results in major journals such as Nature.
Establishment of services in Naver Cloud Platform considering data security
Cloud's serucity services
We are using IPS, IDS, WAF, and Anti-Virus security services for security monitoring activities other than the cloud basic security system.
Ensure data security
Utilizing the cloud database, we secured the availability and integrity of data collected through devices such as storage self-encryption, redundant configuration, automatic backup, and dissipative backup to other regions.
Information protection activities
ISO 27001
After the initial certification of the International Standard for Information Security Management System, re-certification was completed in March 2022. This means that ichrogene is certified for the overall level of security.
CSA Star
As a global security certification that measures the cloud-based gene service competency level, re-certification was completed in March 2022 after the initial certification. This means that security management activities are being carried out effectively for cloud-based services.
Regular monitoring activities
In preparation for physical or technical accidents, we automate service inspections through web service monitoring and analyze activity logs to periodically monitor and supplement to see if there are any intrusions or failures.Only authorized persons can access the personal information processing system, and the database in which customer information is stored is logged in real time through access control. In addition, security activities such as installing vaccines on work terminals and monitoring data utilization are performed regularly or when necessary.
This is a patent information for type 2 diabetes premium service.
Korea Centers for Disease Control and Prevention
The National Institutes of Health, the Korea Centers for Disease Control and Prevention, is an institution affiliated with the Ministry of Health and Welfare that conducts health and medical research and development to prepare for and respond to the risk of infectious diseases and chronic diseases. .
Patent
Information
This report was developed by technology transfer of a patent (Patent No. 10-2254341) related to a method for diagnosing risk groups for type 2 diabetes conducted by the National Institutes of Health, Korea Centers for Disease Control and Prevention.
calculation
method
∑G×A
Genetic risk is predicted by summing the genetic effect (G) of a total of 231 genetic variants multiplied by the number of alleles with influence (A) within an individual's unique genotype.
Analysis methods
Based on the genetic information of more than 150,000 Koreans, we analyze the genetic risk of type 2 diabetes using 175 genetic mutations related to type 2 diabetes and 56 genetic mutations related to fasting blood sugar.
The high risk group (top 1%) with the highest genetic risk of fasting blood sugar has a 2.27 times higher risk of developing type 2 diabetes compared to the general population, and the highest genetic risk group for type 2 diabetes has a 4.58 times higher risk.
In particular, the risk of developing type 2 diabetes increases by 8.08 times in the complex high-risk group with both high fasting blood glucose and high genetic risk of type 2 diabetes. This report predicts the onset of type 2 diabetes by single analysis of ① fasting blood sugar and ② genetic risk of type 2 diabetes, and ③ integrated analysis of each result to provide more accurate results.
Genetic risk of high fasting blood sugar
Type 2 diabetes genetic risk
Integrated genetic risk
Result of risk analysis of type 2 diabetes by the Korea Centers for Disease Control and Prevention
| Analysis type | Target item | Genetic Risk | OR (odds ratio) | 95% confidence interval | statistical significance(p-value) |
|---|---|---|---|---|---|
| Single | fasting blood sugar | Top 20% | 1.67 | 1.57-1.77 | 8.96E-66 |
| Top 10% | 1.9 | 1.77-2.04 | 4.45E-59 | ||
| Top 5% | 2.04 | 1.87-2.23 | 4.65E-59 | ||
| Top 1% | 2.27 | 1.92-2.69 | 3.38E-21 | ||
| type 2 diabetes | Top 20% | 2.27 | 2.14-2.40 | 1.39E-173 | |
| Top 10% | 2.88 | 2.70-3.08 | 8.28E-221 | ||
| Top 5% | 3.43 | 3.17-3.71 | 2.71E-204 | ||
| Top 1% | 4.58 | 3.96-5.30 | 1.61E-93 | ||
| Integration | fasting blood sugar + type 2 diabetes |
Top 20% | 3.26 | 2.91-3.66 | 7.29E-91 |
| Top 10% | 4.34 | 3.79-4.97 | 1.54E-99 | ||
| Top 5% | 5.28 | 4.40-6.34 | 2.75E-71 | ||
| Top 1% | 8.08 | 4.55-14.35 | 9.33E-13 |
How to calculate the incidence rate
ichrogene's iDNADoctor premium report provides more accurate information by calculating the actual incidence rate by genetic risk (risk, average, good) based on epidemiological information and genotype information of 150,000 Koreans from the Korea Centers for Disease Control and Prevention.
calculation method
Your incidence rate = the actual incidence rate of those with the same age and genotype as you among 150,000 Koreans
type 2 diabetes
Genotype-incidence rate linkage
Linking the actual incidence of a population with the same genotype as the tester
Genetic Risk
Provides incidence rates for all genetic risks
calculation method
Your prevalence = the average prevalence of Koreans based on statistical data X your risk
type 2 diabetes
Genotype-incidence rate linkage
Only average statistics that are independent of your genotype are reflected
Integrated genetic risk
Provides only your disease risk figure
calculation method
Your prevalence = the average prevalence of Koreans based on statistical data X your risk
type 2 diabetes
Genotype-incidence rate linkage
Only average statistics that are independent of your genotype are reflected
Integrated genetic risk
Provides only your disease risk figure
Prediction accuracy
iDNADoctor Premium Report has a high prediction accuracy of 85% by comparing the high-risk group (top 1%) predicted based on the genotype information of 150,000 Koreans from the Korea Centers for Disease Control and Prevention and the actual epidemiologic information.
(Examples)
| division | Genetic high risk group | actual number of patients | Prediction accuracy |
|---|---|---|---|
| Top 1% | 100 | 85 | 85.0% |
| Top 5% | 500 | 357 | 71.3% |
| Top 20% | 2 | 1 | 60.0% |
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